Neuro-musculoskeletal interactions in bed rest, hibernation and stroke.

Patterns of bone loss in bed-ridden healthy young male subjects: results from the Long Term Bed Rest Study in Toulouse.

Alendronate as an effective countermeasure to disuse induced bone loss.

Microgravity, similar to disuse immobilization on earth, causes rapid bone loss. This loss is believed to be an adaptive response to the reduced musculoskeletal forces in space and occurs gradually enough that changes occurring during short duration space flight are not a concern. Bone loss, however, will be a major impediment for long duration missions if effective countermeasures are not deve...

Sclerostin and DKK1 levels during 14 and 21 days of bed rest in healthy young men.

OBJECTIVES Wnt signaling pathway may be crucial in the pathogenesis of disuse-induced bone loss. Sclerostin and DKK1, antagonists of the Wnt signaling pathway, were assessed during immobilization by bed rest in young, healthy people. METHODS Two bed rest studies were conducted at the German Aerospace Center in Cologne. 14 days of 6° head-down-tilt bed rest were applied to eight healthy young ...

Tibial Bone Strain in Ambulating Mice Subjected to Partial Weight Bearing

+Christiansen, B A; Roberts, B J; Cloutier, A M; Manoharan, R K; Shah, S R; Bouxsein, M L; +Beth Israel Deaconess Medical Center, Boston, MA [email protected] INTRODUCTION: Mechanical loading is necessary for proper development and maintenance of the musculoskeletal system. There is a great deal of research in small animal models investigating the musculoskeletal response to increased ...

Effects of Transfer Training on Musculoskeletal pain in the Caregiver of a Stroke Patient: A Case Report

The purpose of this case report was to evaluate the effectiveness of training of transfer techniques to a caregiver of a person who had suffered a stroke in decreasing musculoskeletal pain, depression and anxiety. This study adopted a single subject research design to evaluate the effectiveness of transfer-techniques training on musculoskeletal pain, depression, and anxiety in a 25-year-old fem...